The Long Run with Luke Timmerman

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"The Long Run"Antarctic explorer Ernest Shackleton would appreciate today's biotech. Scientific entrepreneurs of the 21st century must be ready for what Shackleton called the “hazardous journey, bitter cold, long months of complete darkness, constant danger, safe return doubtful, honor and recognition in case of success.” Today, the men and women who strive to apply science for the betterment of human health have a historic opportunity. They need stamina and resilience to achieve something meaningful. Biotech’s relationship with the society that sustains it has never been more tenuous. Join host Luke Timmerman for in-depth, thought-provoking conversations with biotech newsmakers pursuing these great opportunities of the 21st century.

Recent Episodes
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    Jun 11, 2025 – 01:10:45
  • Ep179: Ethan Weiss & Josh Lehrer on a New Idea for Cardiovascular Disease & Diabetes
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  • Ep178: Peyton Greenside on ML-Guided Biologics Discovery
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  • Ep177: Kevin Parker on Finding Cancer Drug Targets
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  • Ep176: David Roblin on Building a TechBio Company
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  • Ep175: Andy Scharenberg on in vivo CAR-T cell therapies
    Mar 16, 2025 – 01:10:46
  • Ep174: Najat Khan on the TechBio Movement
    Mar 3, 2025 – 01:07:16
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    Feb 11, 2025 – 00:57:56
  • Ep172: Mostafa Ronaghi on Studying Live Cells at Scale
    Jan 27, 2025 – 01:20:53
  • Ep171: Ram Aiyar on RNA Editing Medicines
    Jan 13, 2025 – 01:01:48
  • Ep170: David Schenkein on Investing in the Future of Biotech
    Jan 2, 2025 – 00:59:52
  • Ep169: Kevin Fitzgerald on the Past & Future of RNAi Medicines
    Dec 11, 2024 – 01:02:28
  • Ep168: Jonathan Bricker on How to Quit Smoking & Prevent Cancer
    Nov 25, 2024 – 01:00:23
  • Ep167: Leslie Williams on transfer RNA therapies
    Nov 6, 2024 – 01:11:28
  • Ep166: Chris Garcia on Engineering Protein Drugs for Cancer, Autoimmunity
    Oct 15, 2024 – 01:03:35
  • Ep165: Zach Hornby on Tackling Cancer Drug Resistance
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  • Ep164: Ted Love and Alan Anderson on Raising the Bar for Sickle Cell Disease Patients
    Sep 5, 2024 – 00:56:39
  • Ep163: Sarah Boyce on RNA Medicines for Muscle Diseases
    Aug 14, 2024 – 01:08:19
  • Ep162: Sean McClain on AI for Biologic Drug Discovery
    Jul 16, 2024 – 01:05:59
  • Ep161: Jeff Stein on a Long-Lasting Flu Drug
    Jul 1, 2024 – 01:08:51
  • Ep160: Abe Ceesay on Precision Neuroscience
    Jun 17, 2024 – 01:08:48
  • Ep159: Jimi Olaghere on Being Functionally Cured of Sickle Cell Disease
    Jun 3, 2024 – 01:07:22
  • Ep158: David Younger and Randolph Lopez on SynBio & AI for Discovery
    May 20, 2024 – 01:00:44
  • Ep157: Vineeta Agarwala of A16Z on Investing in AI for Drug Discovery
    May 1, 2024 – 00:56:33
  • Ep156: David Liu on New Tools and Techniques for Biology
    Apr 16, 2024 – 01:52:57
  • Ep155: Valerie Daggett on Early Detection, and Treatment, of Alzheimer's
    Mar 6, 2024 – 01:02:37
  • Ep154: Robert Ang on CRISPR to Protect Bone Marrow & Attack Cancer
    Feb 9, 2024 – 01:03:14
  • Ep153: Rick Young on Studying Gene Expression for Drug Discovery
    Jan 22, 2024 – 01:01:43
  • Ep152: Jens Eckstein on Investing in Healthy Aging
    Jan 10, 2024 – 01:05:05
  • Ep151: Shelley Force Aldred and Nathan Trinklein on Bispecific Antibodies for Cancer
    Dec 26, 2023 – 01:03:55
  • Ep150: Jeff Jonker on the Small Molecule Drug Discovery Renaissance
    Dec 13, 2023 – 01:03:48
  • Ep149: Nancy Stagliano on Precision Neuroscience
    Nov 29, 2023 – 01:01:53
  • Ep148: Diana Brainard on the Fight Against Infectious Disease
    Nov 13, 2023 – 01:03:27
  • Ep147: Reid Huber on Investing in the Future of Medicine
    Nov 1, 2023 – 01:08:41
  • Ep146: Jeff Huber on Life in Tech and Biotech
    Oct 17, 2023 – 01:47:05
  • Ep145: Lori Lyons-Williams on Targeted Radiopharmaceuticals for Cancer
    Oct 3, 2023 – 01:06:39
  • Ep144: Turning the Tables, Rob Perez Interviews Me
    Sep 19, 2023 – 01:04:58
  • Ep143: Zach Weinberg and Alexis Borisy on Freeing the Biotech Founders
    Sep 6, 2023 – 01:10:25
  • Ep142: Fred Appelbaum on how 'Living Medicine' Came to Be
    Aug 24, 2023 – 00:55:54
  • Ep141: Colin Hill on Digging Deep into Data, Finding New Drug Targets
    Aug 8, 2023 – 01:09:30
  • Ep140: Yung Lie on Supporting Young Scientists with Bold, Brave Ideas
    Jul 24, 2023 – 01:02:40
  • Ep139: Kevin Conroy on Early Detection of Cancer
    Jul 10, 2023 – 01:08:28
  • Ep138: Jodie Morrison on Becoming a Biotech CEO
    Jun 27, 2023 – 01:00:17
  • Ep137: Aaron Ring on Immunotherapy for Cancer & More
    Jun 14, 2023 – 00:56:37
  • Ep136: Deborah Palestrant on Building Biotech Startups
    May 30, 2023 – 00:52:52
  • Ep135: John Maraganore on Developing a New Class of Medicines
    May 8, 2023 – 01:03:51
  • Ep134: Emile Nuwaysir on In Vivo Gene Editing Therapies
    Apr 24, 2023 – 01:16:22
  • Ep133: Catherine Stehman-Breen on Epigenetic Editing Therapies
    Apr 12, 2023 – 01:10:33
  • Ep132: Eric Dobmeier on Treating Kidney Disease
    Mar 28, 2023 – 01:05:44
  • Ep131: Ryan Watts on Neuroscience Drug R&D
    Mar 14, 2023 – 01:05:32
Recent Reviews
  • Lauren Esmay
    Staying Up-to-Date with Timmerman
    I have an alert set for each episode drop. As someone who writes for biotech companies, I enjoy listening to each guest detail their company, mission, and plan to continue to improve every facet of healthcare. Luke has amazing interview skills and this is one of my top 3 podcasts!
  • ladyscientistpodcast
    Loved the last 2 episodes!
    Discussions around gene regulation with Rick Young and finding your purpose with Robert Ang really stood out to me. Thanks for sharing such great stories.
  • JPG1618
    A treat while social distancing
    During these unusual times, I have found the human stories behind the long run and the great people in our industry a wonderful treat. I listen while walking the hills of SF and feel connected to our community even when we are apart. Thanks Luke. Keep up the awesome work focused on people.
  • 1-2-3 Josh
    Great Podcast
    I am someone that is not in the bio tech world, but find it absolutely fascinating. Luke has a great ability as an interviewer to ask questions that makes complex bio tech topics, understandable and not condescending to people are not immersed in the bio tech world.
  • Oncoproteins
    Let the guests talk more, significantly more
    The list of the guests is fantastic. I only wish that the interviewer would let the guests talk and explain things significantly more. I don’t believe we the listeners are very interested in the interviewer’s personal views or his non-expert interpretations, some of which are often both shallow and unnecessary.
  • yul51471
    Interesting guests—give them the spotlight
    Lots of interesting and unique perspectives here—would suggest that Luke talk/ramble less and focus on the interviewee. At times it feels like Luke imposes his views/input on the guest which takes away from the story.
  • DW Howell
    Great Podcast!
    I never miss and episode. Would love to see you get one of the Incept founders on. Fred Khosravi and Amar Sawhney have a unique business model and would be a great interview for Luke.
  • BTM12
    Kick it up a notch
    Big fan of Luke! But he needs to drink 2 shots of espresso before these interviews and watch a couple mainstream cooking shows to see how to keep audiences engaged. These could probably be half the length with the same content. Otherwise, great podcast content and guests!!
  • Keermaster
    A needle in the haystack of biotechnology
    A great listen for anyone who is going into industry or is an investor in biotech. I would love to see more episodes of deans of biotech grad schools to understand their point of view as well. Thank you, Luke!
  • Neptune from Norfolk
    Episodes 15 and 16
    The listener cannot hear guest on episodes 15 and 16.
  • Devehf
    Audio quality suffers
    Biotech historians of the future will spend hours restoring the inaudible recordings with the important pioneers who Luke has access to. I wish I could hear some of the recent interviews. If I were producing these I would scrap the junk and spend more time and money on production equipment and process. Send Luke $ so he can do this. These are important interviews for those of us following the astounding explosion of new therapies yielding incredible benefit to our species.
  • Siddaraju Boregowda
    Only thing needs to change about the podcast
    Vicki Sato and Robins interviews are inaudible.
  • Cchu1348
    Today’s leading healthcare innovators
    fascinating perspectives. wish it was twice as long.
  • WorldWideWade
    The indispensable biotech journalist
    No one beats Luke for the breadth of his biotech knowledge, the depth of his network of sources, and the keenness of his understanding of the drug development process. Everyone who works or invests in this industry needs to be listening.
  • ender405
    Great topic, some feedback
    Great idea for a podcast that doesn't exist today. I think this will help laypeople understand the massive risks people take in biotech and how hard it can be to push science forward. I'm a subscriber to the TR and love the content you make Some feedback to make the podcast even better: Focus more on the origin story of the company and of the interviewees. There is such a rich fabric of events to discuss on the early development of RNAi, for example, but this interview barely touched on any of it! I also felt like I didn't learn anything new about John. Keep questions short and leading questions few and far between. On the drug pricing issue in particular I felt like you did most of the talking. I want to hear John's point of view! Limit the amount of current events discussion. This content will be evergreen if it focuses on origin story, science, progress, pitfalls, triumphs, etc. Hope this helps. Can't wait for more episodes!
  • Rayjayman
    Great for the common investor!
    I really enjoy the insights in biotech drug development. It really fills a need in the podcast space.
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